Quick thoughts:
Got this roughly two weeks ago, and have probably put in close to forty hours. Result is that I'm in a problem of thirds: one part hates this game, one part wants to hate it but can't, and one part loves it.
Primarily the disapproval comes from technical glitches, uncanny valley, some initial problems with the interface (it could be drastically simplified to be more streamlined), and An initial "this sucks because I don't have enough ammo and can't get enough cash."
Gave it some time and it comes around much better after that breaking-in period. While I will say roughly 80% of the game is purely just walking, part of that is pretty good in and of itself. The other 20% is generally okay, even if the dialogue is abysmal in places. Getting various missions is a lot of fun, building your character is worthwhile, and seeing the changes you enact in the world based on your actions is neat. Hell just scavenging is pretty fun.
Combat is...passable, I actually think full-on FPS would have made a little more sense. But that would be herecticism to this series's roots, so I understand why it's not like that. Besides, the VATS movies sort of look like a futuristic Discovery Channel, except you are watching mutant heads asplode.
I think if they cut out a bit of the fluff, refined the perk system a bit more (c'mon, most are useless), made the combat slightly more visceral, it would be an exquisite game. As it stands, I must admit I have a lot of fun with it, and always look forward to playing it more. So I guess that means Bethesda can claim mission accomplished.